Investigación

Quienes somos

La subdirección de docencia de la Escuela de Medicina, tiene como función principal, coordinar, promover y estimular el desarrollo de las actividades de investigación de los académicos y estudiantes.

Contamos con dos centros de investigaciones, además de grupos de investigación alojados en el campus central y campus clínicos

 

Centros de Investigación 

CIBAP: Programa centro de Investigación biomédica y aplicada (www.cibap.usach.cl):

El CIBAP, cuenta con un espacio de 120 mts2 construidos, ubicados en el campus central de la Universidad. La subdivisión de los espacios de trabajo obedecen a funciones y no a investigadores específicos tal que se cuenta con: una área limpia de cultivo celular, un laboratorio de biología celular, molecular y bioquímica, un laboratorio de histología y síntesis química, un área de mantención de Drosophila,  una sala de electrofisiologia, un área de microscopia, dos áreas de mantención y manipulación de modelos animales, un área de ingeniería biomédica. Actualmente, el CIBAP acoge a 10 investigadores,  cuyas líneas de investigación incluyen: Farmacología, Química medicinal, Fisiología celular, Genética, Neurofisiología, Cáncer y Epigenética, Histología e Ingeniería biomédica. Información detallada de sus investigadores, productividad científica y líneas de investigación se encuentran disponibles en su pagina web.

Departamento de medicina respiratoria Infantil  Hospital El Pino (http://www.mri.usach.cl/)

El Departamento de MRI fue creado con el fin de solucionar los problemas de salud respiratoria a los niños que viven en las comunas de San Bernardo y El Bosque, bajo la cobertura del Hospital CRS El Pino, localizado en el área sur de Santiago, la ciudad capital de Chile. Las labores asistenciales, docentes y de investigación se desarrollan principalmente en las cinco unidades que forman el Dpto. de MRI y que son: Unidad de Clínica Ambulatoria; Unidad de Broncoscopía; Unidad de Función Pulmonar en Niños; Unidad de Función Pulmonar en Lactantes; Laboratorio de Análisis Biomolecular y Unidad de Docencia e Investigación.  Información detallada de sus investigadores, productividad científica y líneas de investigación se encuentran disponibles en su página web.

Laboratorios de Investigación

  • Laboratorio de Embriología Humana, a cargo del Dr. Jaime Pereda T.
  • Laboratorio de Neurofarmacología y Comportamiento, a cargo del Dr. Patricio Sáez B
  • Grupo de investigación de medicina basada en la evidencia a cargo de la Dra Vivienne C. Bachelet

 

Proyectos de Investigación vigentes (2015-2018)

  • Fishing for complements: design of compounds that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their ligand binding sites (FONDECYT regular2013-2017) Dr. Miguel Reyes Parada
  • Pharmacological characterization of ecstasy derivatives as tools for the modulation of entactogenic-like effects in rats. ( DICYT regular 2014-2016) Dr Patricio Sáez Briones
  • Caracterización de la salud laboral y riesgo de accidentes laborales de los trabajadores que cubren turnos urgencia en Chile (Asociación Chilena de Seguridad, SUSESO 2015-2016) Dra Vivienne Bachelet
  • Proyecto “Return to Home" Chile International Brain Organization (IBRO,2015-2016) Dr Christian Cea-Del Rio CA.
  • Análisis de instrumentos para la evaluación del desarrollo psicomotor en niños de 7 a 48 meses. (Ministerio de Desarrollo Social 2015-2016) Dra Vivienne Bachelet.
  • Interacción entre jagunal, y npc1a en Drosophila melanogaster: relación con la enfermedad de Niemann-Pick tipo C (DICYT regular 2015-2017) Dr. Luis Milla Brito
  • Caracterización de los accidentes laborales con resultado de muerte en Chile: estudio transversal sobre registros de 2014-2015 (Mutual de Seguridad de la Cámara Chilena de la Construcción, SUSESO 2015-2016) Dra Vivienne Bachelet
  • Abnormal developmental progression of inhibitory neurotransmission in the somatosensory cortex of FXS (FONDECYT iniciación 2015-2018) Dr Christian Cea Del Rio
  • Expresión de moléculas de adhesión celular (galectina-3, galectina-9, trofinina, tastina y biotina) en el epitelio de la trompa de Falopio humana a lo largo del ciclo menstrual. (DICYT regular 2015-2017) Dr. Carlos Godoy Guzmán
  • Revisión panorámica sobre accidentes de tránsito de origen ocupacional. (Asociación Chilena de Seguridad 2016) Vivienne Bachelet.
  • Determinación de costos de implementación del programa de vigilancia salud para trabajadores expuestos a hipobaria intermitente crónica por gran altura geográfica de ACHS. (Asociación Chilena de Seguridad, SUSESO 2016-2017) Dra Vivienne Bachelet
  • Efectividad del tratamiento con acupuntura en trabajadores de la ACHS de la Región Metropolitana con problemas de salud mental de origen laboral: ensayo clínico aleatorizado pragmático. (Asociación Chilena de Seguridad, SUSESO 2016-2017) Dra Vivienne Bachelet
  • Método para el aislamiento y análisis de histonas de plasma, proveniente de tumores, para ser usadas en la detección y pronósticos epigenéticos en la evaluación de las enfermedades neoplásicas. (DICYT regular 2016 2018) Dr. Pedro Rodríguez Collazo
  • Estudio de las propiedades antibacterianas de flavonoides prenilados y cromonas C2-alquiladas en cepas multirsistentes: potenciacion de su actividad a través del sinergismo (DICYT REGULAR 2016-2018). Dra Yesseny Amneris Vasquez Martinez
  • Estudio determinación de brecha de médicos generales y especialistas según metodología de tasas de uso de prestaciones médicas y especializadas en Chile. (Ministerio de Salud 2016-2018) Dra Vivienne Bachelet
  • Exactitud diagnóstica del instrumento Análisis de la Carga de Trabajo para determinar la ausencia o presencia de riesgos laborales en el puesto de trabajo. (Asociación Chilena de Seguridad, SUSESO 2016-2018) Dra Vivienne Bachelet
  • Expresión de marcadores endoteliales en la pared del Saco Vitelino humano: Estudio morfológico-inmunohistoquimico (DICYT regular 2016-2018) Dr Jaime  Pereda Tapiol.
  • Resumen de evidencia sobre tiempos de espera para cirugías electivas para apoyar la toma de decisiones en políticas de salud (Ministerio de Salud 2017-2018) Dra  Vivienne Bachelet.
  • Evaluación de efectos de isoflavona e isoflavana en mercadores de estrés oxidativo e inflamación in vitro, ex vivo y un modelo animal de obesidad (DICYT regular 2016-2018) Dra Victoria Espinosa Ferrada.
  • Síntesis, propiedades Anti-inflamatorias y Estudios  Computacionales de Derivados de Chalconas como Inhibidores de 5- LOX (Continuidad FONDECYT DICYT-USACH 2016-2018) Dra  Carolina Mascayano, Dra Victoria Espinosa.
  • Estudios comparativos y modelos de algoritmos computacionales personalizados orientados a diabetes en sistemas de información por internet (DICYT postdoctorado 2016-2017) Dr Victor Rocco Montenegro.
  • Hybrid cathinones oxazolines and benzofuranes as tools for modulating MDMA (3,4- methylenedioxymethamphetamine)- like effects in rats (DICYT regular 2017-2019) Dr Patricio Sáez Briones
  • FONDEF adulto mayor (FONDEF 2017-2019) Dr Cristian Caparro, Dr Rafael Barra              .
  • Fondo para la Innovación y competitividad Regional (FIC R 2017-2020) Profesora Orietta nicoliss, Dr Rafael Barra.
  • Proyecto Fondecyt de Postdoctorado (FONDECYT2017-2020) Profesora  Trinidad Mariqueo, Dr Rafael Barra.
  • Multisteric drugs: design of polypharmacological agents that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their multiple binding sites (FONDECYT regular 2017-2021) Dr Miguel Reyes Parada.
  • Identificación y caracterización de células madre y su nicho en la trompa de Falopio humana para su utilización de ingeniería tisular.(DICYT regular 2018-2020) Dr. Carlos Godoy Guzmán.

 

Publicaciones vigentes (2015-2018)

Publicaciones 2018

•             Daniela Toro-Ascuy; Alvaro Santibañez; Victor Peña; Carolina Beltran; Luis Cottet; Cristian Molina; Margarita Montoya; Nicolas Sandoval; Yesseny Vasquez-Martínez; Carolina Mascayano, Marcelo Cortez-San Martín            (2018) “ Functional study of the Infectious Salmon Anaemia virus (ISAV) nucleoprotein by a minigenome assay: Importance of residues R189, R194, R302, and K325 in RNA binding activity and Ribonucleoprotein complex in Piscine Orthomyxovirus”             Virology,

•             Gonzalo P. Barriga, Dusan Boric-Bargetto, Marcelo Cortez San Martin, Víctor Neira, Harm van Bakel, Michele Thompsom, Rodrigo Tapia, Daniela Toro-Ascuy, Lucila Moreno, Yesseny Vásquez-Martínez, Michel Sallaberry, Fernando Torres-Pérez, Daniel González-Acuña, Rafael A. Medina, Barriga, (2016) “Avian Influenza Virus H5 Strain with North American and Eurasian Lineage Genes in an Antarctic Penguin”,  Emerg Infect Dis.22(12):2221-2223. http://dx.doi.org/10.3201/eid2212.161076,DOI:10.3201/eid2212.161076.

•             Godoy-Guzmán C, Nuñez C, Orihuela P, Campos A, Carriel V.Distribution of extracellular matrix molecules in human uterine tubes during the menstrual cycle: a histological and immunohistochemical analysis.        J Anat. 2018 Jul;233(1):73-85. doi: 10.1111/joa.12814. Epub 2018 Apr 16.

•             Chacón M, Noh SH, Landerretche J, Jara JL.Comparing Models of Spontaneous Variations, Maneuvers and Indexes to Assess Dynamic Cerebral Autoregulation. Acta Neurochir Suppl. 2018;126:159-162. doi: 10.1007/978-3-319-65798-1_33.

•             Mallol J, Aguirre V, Mallol-Simmonds M, Matamala-Bezmalinovic A, Calderón-Rodriguez L, Osses-Vergara F. Changes in the prevalence of asthma and related risk factors in adolescents: Three surveys between 1994 and 2015. Allergol Immunopathol (Madr). 2018 Nov 29. pii: S0301-0546(18)30137-X. doi: 10.1016/j.aller.2018.10.001

•             Heidari S, Bachelet VC.  Sex and gender analysis for better science and health equity. Lancet. 2018 Oct 27;392(10157):1500-1502. doi: 10.1016/S0140-6736(18)32619-9.

•             Nuñez MT., Chana-Cuevas P New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases. Pharmaceuticals (Basel). 2018 Oct 19;11(4). pii: E109. doi: 10.3390/ph11040109.

•             D'Elia C, Mallol J, Solé D Prevalence of recurrent wheezing during the first year of life in Setúbal district, Portugal. Allergol Immunopathol (Madr). 2018 Aug 2. pii: S0301-0546(18)30083-1. doi: 10.1016/j.aller.2018.04.006.

•             Aranda CS, Wandalsen G, Bianca ACCD, Dantas EO, Mallol J, Solé D. Temporal comparison of wheezing prevalence in the first year of life in São Paulo: international study of wheezing in infants.           Rev Paul Pediatr. 2018 Oct-Dec;36(4):445-450. doi: 10.1590/1984-0462/;2018;36;4;00016.

•             Núñez-Vivanco G, Fierro A, Moya P, Iturriaga-Vásquez P, Reyes-Parada M. 3D similarities between the binding sites of monoaminergic target proteins. PLoS One. 2018 Jul 20;13(7):e0200637. doi: 10.1371/journal.pone.0200637. eCollection 2018.

•             Dib T, Martínez-Pinto J, Reyes-Parada M, Torres GE, Sotomayor-Zárate R. Neonatal programming with testosterone propionate reduces dopamine transporter expression in nucleus accumbens and methylphenidate-induced locomotor activity in adult female rats. Behav Brain Res. 2018 Jul 2;346:80-85. doi: 10.1016/j.bbr.2017.12.001. Epub 2017 Dec 6.

•             Mallol J, Solé D, Aguirre V, Chong H, Rosario N, García-Marcos L; EISL Study Group. Changes in the prevalence and severity of recurrent wheezing in infants: The results of two surveys administered 7 years apart. (2018) J Asthma. Nov;55(11):1214-1222. doi: 10.1080/02770903.2017.1403625. Epub 2017 Dec 12.

•             Godoy-Guzman, C.; Fuentes, J. L.; Osses, M.; et ál..          The Uterine Tube: From Herophilus to Horacio Croxatto International journal of morphology   Volumen: 36   Número: 2   Páginas: 387-390   Fecha de publicación: JUN 2018

•             Godino, A  ; Renard, GM. (2018)  Effects of alcohol and psychostimulants on the vasopressin system: Behavioural implications Journal of neuroendocrinology 30(8) DOI:10.1111/jne.12611

•             Cassels, Bruce K.; Saez-Briones, Patricio Dark Classics in Chemical Neuroscience: Mescaline. (2018) Acs Chemical Neuroscience   Volumen: 9   Número: 10   Número especial: SI   Páginas: 2448-2458

•             Enrique Schwarze, Juan; Borda, Paula; Vasquez, Pamela; et ál..  Is the risk of preeclampsia higher in donor oocyte pregnancies? A systematic review and meta-analysis. Jornal brasileiro de reproducao assistida   Volumen: 22   Número: 1   Páginas: 15-19   Fecha de publicación: JAN-MAR 2018

•             Enrique Schwarze, Juan; Canales, Johana; Crosby, Javier; et ál..  DHEA use to improve likelihood of IVF/ICSI success in patients with diminished ovarian reserve: A systematic review and meta-analysis. Jornal brasileiro de reproducao assistida   Volumen: 22   Número: 4   Páginas: 369-374   Fecha de publicación: OCT-DEC 2018

•             Schwarze, Juan-Enrique; Pablo Ceroni, Juan; Ortega-Hrepich, Carolina; et ál..      Does acupuncture the day of embryo transfer affect the clinical pregnancy rate? Systematic review and meta-analysis. Jornal brasileiro de reproducao assistidA   Volumen: 22   Número: 4   Páginas: 363-368   Fecha de publicación: OCT-DEC 2018

 

Publicaciones año 2017

•             Mallol J, Solé D, Aguirre V, Chong H, Rosario N, García-Marcos L; EISL Study Group. Changes in the prevalence and severity of recurrent wheezing in infants: The results of two surveys administered 7 years apart.  J Asthma. 2017 Dec 12:1-9.doi: 10.1080/02770903.2017.1403625. PubMed PMID: 29231772.

•             Braithwaite IE, Stewart AW, Hancox RJ, Murphy R, Wall CR, Beasley R, Mitchell EA  ISAAC Phase Three Study Group. Body mass index and vigorous physical activity in children and adolescents: an international cross-sectional study    Acta Paediatr. 2017 Aug;106(8):1323-1330. doi: 10.1111/apa.13903. Epub 2017 Jun 6. PubMed PMID: 28471494.

•             Aranda CS, Wandalsen GF, Dela Bianca AC, Moraes L, Lamenha Medeiros M, Mallol J, Solé D. Wheezing and the first thousand days of life.   Pediatr Allergy Immunol. 2017 Jun;28(4):397-400. doi: 10.1111/pai.12710. Epub 2017 Apr 11

•             Szulman GA, Freilij H, Behrends I, Gentile Á, Mallol J.      [Recurrent wheezing: prevalence and associated factors in infants from Buenos Aires City, Argentina].     Bol Med Hosp Infant Mex. 2017 Nov - Dec;74(6):419-426. doi: 10.1016/j.bmhimx.2017.08.001. Epub 2017 Nov 22.

•             Ellwood P, Asher MI, Billo NE, Bissell K, Chiang CY, Ellwood EM, El-Sony A, García-Marcos L, Mallol J, Marks GB, Pearce NE, Strachan DP.               The Global Asthma Network rationale and methods for Phase I global surveillance: prevalence, severity, management and risk factors.        Eur Respir J. 2017 Jan 11;49(1). pii: 1601605. doi: 10.1183/13993003.01605-2016. Print 2017

•             Urrutia-Pereira M, Oliano VJ, Aranda CS, Mallol J, Solé D.              Prevalence and factors associated with smoking among adolescents.     J Pediatr (Rio J). 2017 May - Jun;93(3):230-237. doi: 10.1016/j.jped.2016.07.003. Epub 2016 Nov 22.

•             Villanueva A., Falcon P., Espinoza N, Solano L.R., Milla L.A., Hernandez- SanMiguel E., Torres V, Sanchez-Gomez P, Palma V          The Netrin-4/Neogenin-1 axis promotes neuroblastoma cell survival and migration.        Oncotarget. (2017) Feb 7;8(6):9767-9782

•             Peijun Li, Xiaoqin Fu, Nathan A. Smith, Julian Curiel, Milagros J. Tenga, Brandon Martin, Samuel Freedman, Christian Cea-Del Rio, Livio Oboti, Tammy N. Tsuchida, Chima Oluigbo, Amanda Yaun, Suresh N. Magge, Brent O’Neill, Amy Kao, Tesfaye G. Zelleke, Dewi T, Depositario-Cabacar, Svetlana Ghimbovich, Susan Knoblach, Chen-Ying Ho, Joshua Corbin, Howard P. Goodkin, Stefano Vicini, Molly M. Huntsman, William D. Gaillard, Gregorio Valdez, and Judy S. Liu.    Loss of Clock results in dysfunction of brain circuits underlying focal epilepsy”. Neuron. Oct 11;96(2):387-401.e6.  https://doi.org/10.1016/j.neuron.2017.09.044

•             Ahumada C., Bahamondes C., Cerda C., Silva RA., Cruz G., Moya PR., Sotomayor-Zárate R., Renard GM.                AMPHETAMINE TREATMENT AFFECTS THE EXTRA-HYPOTHALAMIC VASOPRESSINERGIC SYSTEM IN A SEX- AND NUCLEUS-DEPENDENT MANNER”.J Neuroendocrinol. Apr;29(4).

•             Brenda Vera, Karina Vázquez, Carolina Mascayano, Ricardo A. Tapia, Victoria Espinosa, Jorge Soto-Delgado, Cristian O. Salas & Margot Paulino           Structural Analysis and Molecular Docking of Trypanocidal Aryloxy-quinones in Trypanothione and Glutathione Reductases: A Comparison with Biochemical Data           . J Biomol Struct Dyn. 2017 Jun;35(8):1785-1803. doi: 10.1080/07391102.2016.1195283

•             Bachelet, V. C.   What are preprints? Medwave, 17(9), e7091. https://doi.org/10.5867/medwave.2017.09.7091

•             Bachelet, V. C. We must start applying author processing charges. Medwave, 17(8), e7070.

•             Bachelet, V. C. Medwave’s editorial history, policies and guidelines: 1. Description. Medwave, 17(3), e6908–e6908. https://doi.org/10.5867/medwave.2017.03.6908

•             Bachelet, V. C. Medwave’s editorial history, policies and guidelines: 3. Section policies. Medwave, 17(3), e6810–e6810. https://doi.org/10.5867/medwave.2017.03.6810

•             Bachelet, V. C Medwave’s editorial history, policies and guidelines: 2. Editorial policies. Medwave, 17(3), e6909–e6909. https://doi.org/10.5867/medwave.2017.03.6909

•             Bachelet, V. C Medwave’s editorial history, policies and guidelines: 4. Author instructions and journal guidelines. Medwave, 17(3), e6911–e6911. htps://doi.org/10.5867/medwave.2017.03.6911

•             Pessoa-Mahana H, Silva-Matus P, Pessoa-Mahana CD, Chung H, Iturriaga-Vásquez P, Quiroz G, Möller-Acuña P, Zapata-Torres G, Saitz-Barría C, Araya-Maturana R, Reyes-Parada M. Synthesis and Docking of Novel 3-Indolylpropyl Derivatives as New Polypharmacological Agents Displaying Affinity for 5-HT1A R/SERT. Arch Pharm (Weinheim). 2017 Jan;350(1). doi: 10.1002/ardp.201600271. Epub 2016 Dec 16

•             Rodriguez-Blazquez, C (Rodriguez-Blazquez, Carmen)[ 1,2 ] ; Alvarez, M (Alvarez, Mario)[ 3 ] ; Arakaki, T (Arakaki, Tomoko)[ 4 ] ; Arillo, VC (Campos Arillo, Victor)[ 5 ] ; Chana, P (Chana, Pedro)[ 6 ] ; Fernandez, W (Fernandez, William)[ 7 ] ; Garretto, N (Garretto, Nelida)[ 4 ] ; Martinez-Castrillo, JC (Carlos Martinez-Castrillo, Juan)[ 8 ] ; Rodriguez-Violante, M (Rodriguez-Violante, Mayela)[ 9 ] ; Serrano-Duenas, M (Serrano-Duenas, Marcos)[ 10,11,12 ] . Self-Assessment of Disability in Parkinson's Disease: The MDS-UPDRS Part II Versus Clinician-Based Ratings                movement disorders clinical practice(4)4:529-535 .DOI 10.1002/mdc3.12462 Por:

  • Garcia-Martinez, Laura; Campos, Fernando; Godoy-Guzman, Carlos; et ál Encapsulation of human elastic cartilage-derived chondrocytes in nanostructured fibrin-agarose hydrogels HISTOCHEMISTRY AND CELL BIOLOGY   Volumen: 147   Número: 1   Páginas: 83-95

 

Publicaciones año 2016

•             Rodriguez P, Rojas J.       cAMP-Induced Histones H3 Dephosphorylation Is Independent of PKA and MAP Kinase Activations and Correlates With mTOR Inactivation.        J Cell Biochem. 2016 Mar;117(3):741-50. doi: 10.1002/jcb.25359. Epub 2015 Sep 17.

•             Pacheco-Gonzalez RM, Mallol J, Solé D, Brand PL, Perez-Fernandez V, Sanchez-Solis M, Garcia-Marcos L                EISL Study Group. Factors associated with the time to the first wheezing episode in infants: a cross-sectional study from the International Study of Wheezing in Infants (EISL)NPJ Prim Care Respir Med. 2016 Jan 21;26:15077. doi: 10.1038/npjpcrm.2015.77. PubMed PMID: 26796896; PubMed Central PMCID: PMC4721498.

•             Mallol J, Solé D, Garcia-Marcos L, Rosario N, Aguirre V, Chong H, Urrutia-Pereira M, Szulman G, Niederbacher J, Arruda-Chavez E, Toledo E, Sánchez L, Pinchak C;         EISL Latin American Group. Prevalence, Severity, and Treatment of Recurrent Wheezing During the First Year of Life: A Cross-Sectional Study of 12,405 Latin American Infants.                Allergy Asthma Immunol Res. 2016 Jan;8(1):22-31. doi: 10.4168/aair.2016.8.1.22. Epub 2015 Jul 27. PubMed PMID: 26540498; PubMed Central PMCID: PMC4695404.

•             Mallol J, Aguirre V, Gallardo A, Cortez E, Sánchez C, Riquelme C, Córdova P, Martínez M, Galindo A. Effect of once-daily generic ciclesonide on exhaled nitric oxide in atopic children with persistent asthma Allergol Immunopathol (Madr).2016 Mar-Apr;44(2):106-12. doi: 10.1016/j.aller.2015.01.011. Epub 2015 May 20.PubMed PMID: 26001339.

•             Pacheco-Gonzalez, R. M., Mallol, J., Solé, D., Brand, P. L. P., Perez-Fernandez, V., Sanchez-Solis, M. & Garcia-Marcos, L.           Factors associated with the time to the first wheezing episode in infants: A cross-sectional study from the International Study of Wheezing in Infants (EISL). 21 Jan 2016 In : npj Primary Care Respiratory Medicine. 26, 15077

•             Mallol, J. , Solé, D. , Garcia-Marcos, L. , Rosario, N. , Aguirre, V. , Chong, H. , Urrutia-Pereira, M. , Szulman, G. , Niederbacher, J. , Arruda-Chavez, E. , Toledo, E. , Sánchez, L. , Pinchak, C. , Aranda, C. , Bianca, C. D. , de Oliveira, C. M. , Takano, O. A. , Ivancevich, J. C. , Jorge, P. P. D. O. , Cuadros-Mendoza, C. A. & 13 others.            Prevalence, severity, and treatment of recurrent wheezing during the first year of life: A cross-sectional study of 12,405 Latin American infants 2016 In : Allergy, Asthma and Immunology Research. 8, 1, p. 22-31 10 p

•             Aranda, C. S., Wandalsen, G., Fonzar, L., Bianca, A. C. D., Mallol, J. & Solé, D        Risk factors for recurrent wheezing - International Study of Wheezing in Infants (EISL) phase 3      . 1 Jan 2016 In : Allergologia et Immunopathologia. 44, 1, p. 3-8 6 p

•             Núñez-Vivanco, G., Valdés-Jiménez, A., Besoaín, F. & Reyes-Parada, M. Geomfinder: A multi-feature identifier of similar three-dimensional protein patterns: A ligand-independent approach. 18 Apr 2016 In : Journal of Cheminformatics. 8, 1, 131

•             Dressler, D., Altenmueller, E., Bhidayasiri, R., Bohlega, S., Chana, P., Chung, T. M., Frucht, S., Garcia-Ruiz, P. J., Kaelin, A., Kaji, R., Kanovsky, P., Laskawi, R., Micheli, F., Orlova, O., Relja, M., Rosales, R., Slawek, J., Timerbaeva, S., Warner, T. T. & Saberi, F. A.        Strategies for treatment of dystonia       1 Mar 2016 In : Journal of Neural Transmission. 123, 3, p. 251-258 8 p.

•             Espinosa P., Silva R.A., Riquelme R., González L.F., Sanguinetti N.K., Venegas F., Cruz G., Renard G.M., Moya P.R., Sotomayor-Zárate R.            PROGRAMMING OF DOPAMINERGIC NEURONS BY NEONATAL SEX HORMONE EXPOSURE: EFFECTS ON DOPAMINE CONTENT AND TYROSINE HYDROXYLASE EXPRESSION IN ADULT MALE RATS. Neural Plasticity, vol. 2016, Article ID 4569785.

•             Bachelet, V. C.   Two doses and not three for the human papilloma virus vaccine in Chile.             Medwave, 16(1), e6373–e6373. https://doi.org/10.5867/medwave.2016.01.6373

•             Bachelet, V. C.   Publication ethics and COPE.     Medwave, 16(4), e6456–e6456. https://doi.org/10.5867/medwave.2016.04.6456

•             Margot Paulino, Elena Alvareda, Federico Iribarne, Pablo Miranda, F.Victoria Espinosa, Sara Aguilera & Helena Pardo     Towards the understanding of the molecular basis for the inhibition of COX-1 and COX-2 by phenolic compounds present in Uruguayan propolis and grape pomace, J Biomol Struct Dyn. 2016 Dec;34(12):2643-2657

•             Avendaño-Herrera R, Irgang R., Poblete-Morales M., Vásquez-Martínez Y, Robles C., Toro-Ascuy D, Cortez-San Martín M.           Predominant bacteria associated with the Antartic black rock cod (Notothenia coriiceps, Richardson 1844) from King George Island (Southern Shetlands) in the Antartica”. Bull. Eur. Ass. Fish Pathol., 36(6):246-255.

•             Juri, Venegas, P  ; Chana, P  ; Kramer, V  ; Prusso, R ; Amaral, H . Comparison between odor discrimination, substantia nigra echogenicity and nigrostriatal dopaminergic activity measured by 18F.PR04 pet in Parkinsonian syndromes. JOURNAL OF THE NEUROLOGICAL SCIENCES 357(supll1) E52-E52. DOI:10.1016/j.jns.2015.08.210

•             Pellegrini-Belinchon, J (Pellegrini-Belinchon, J.); Lorente-Toledano, F (Lorente-Toledano, F.); Galindo-Villardon, P (Galindo-Villardon, P.); Gonzalez-Carvajal, I (Gonzalez-Carvajal, I.); Martin-Martin, J (Martin-Martin, J.); Mallol, J (Mallol, J.); Garcia-Marcos, L (Garcia-Marcos, L.)               Factors associated to recurrent wheezing in infants under one year of age in the province of Salamanca, Spain: Is intervention possible? A predictive model. ALLERGOLOGIA ET IMMUNOPATHOLOGIA  44( 5): 393-399  DOI: 10.1016/j.aller.2015.09.001  Fecha de publicación: SEP-OCT 2016 

•             Urrutia-Pereira, M (Urrutia-Pereira, M.); Oliano, VJ (Oliano, V. J.); Mallol, J (Mallol, J.); Sole, D (Sole, D.)                Smoking among adolescents from a countryside city of Brazil and the future impact in respiratory diseases                ALLERGY  Abstract de reunión: 546  Volumen: 71  Número especial: SI  Páginas: 255-255  Suplemento: 102  Fecha de publicación: AUG 2016 

•             Aranda, C (Aranda, C.); Wandalsen, G (Wandalsen, G.); Moraes (Moraes, L.); Dela Bianca, AC (Dela Bianca, A. C.); Lamenha (Lamenha, M.); Mallol, J (Mallol, J.); Sole, D (Sole, D.)         Wheezing and the first thousand days of life. ALLERGY  Abstract de reunión: 791  Volumen: 71  Número especial: SI  Páginas: 361-361  Suplemento: 102  Fecha de publicación: AUG 2016 

•             Neto, HJC (Neto, Herberto J. Chong); Rosario, NA (Rosario, Nelson A.); Sole, D (Sole, Dirceu); Mallol, J (Mallol, Javier)  Treatment Patterns of Recurrent Wheezing in Infants: Two Surveys Separated By Seven Years. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY  Abstract de reunión: 18  Volumen: 137  Número: 2  Páginas: AB6-AB6  Suplemento: S  Fecha de publicación: FEB 2016 

•             Mallol, J  Sole, D ; Garcia-Marcos, L ; Rosario, N ; Aguirre, V; Chong, H ; Urrutia-Pereira, M; Szulman, G ; Niederbacher, J; Arruda-Chavez, E; Toledo, E ; Sanchez, L ; Pinchak, C .Prevalence, Severity, and Treatment of Recurrent Wheezing During the First Year of Life: A Cross-Sectional Study of 12,405 Latin American Infants                ALLERGY ASTHMA & IMMUNOLOGY RESEARCH  Volumen: 8  Número: 1  Páginas: 22-31  DOI: 10.4168/aair.2016.8.1.22  Fecha de publicación: JAN 2016 

 

Publicaciones año 2015

•             Draaisma, E. , Garcia-Marcos, L. , Mallol, J. , Solé, D. , Pérez-Fernández, V. , Brand, P. L. P. , Leite, A. M. , Bessa, O. C. , Prestes, E. X. , Sarinho, E. , Medeiros, D. , Camargos, P. , Fernández-Fontes, M. J. , Rocha, W. , Bianca, C. D. , Rosario, N. , Chong, H. , Fischer, G. B. , Cepeda, A. E. , Aguirre, V. & 20 others      A multinational study to compare prevalence of atopic dermatitis in the first year of life    1 Jun 2015 In : Pediatric Allergy and Immunology. 26, 4, p. 359-366 8 p.

•             Pellegrini-Belinchón, J., Lorente-Toledano, F., Galindo-Villardón, P., González-Carvajal, I., Martín-Martín, J., Mallol, J. & García-Marcos, L.     Factors associated to recurrent wheezing in infants under one year of age in the province of Salamanca, Spain: Is intervention possible? A predictive model30 Jul 2015 (Accepted/In press) In : Allergologia et Immunopathologia.

•             Wandalsen, G. F., Borges, L. V., Barroso, N., Rota, R., Suano, F., Mallol, J., Solé, D., Prestes, E. X., Neto, H. C., Filho, N. S. R., Dela Bianca, A. C., Medeiros, D., Sarinho, E., Aranda, C., Moraes, L. S., Fernandes-Pontes, M. J. & Camargos, P       Gender differences in the relationship between body mass index (BMI) changes and the prevalence and severity of wheezing and asthma in the first year of life. 1 Nov 2015 In : Allergologia et Immunopathologia. 43, 6, p. 562-567 6 p.

•             Garcia-Marcos, L., Mallol, J., Solé, D., Brand, P. L. P., Martinez-Torres, A. & Sanchez-Solis, M.       Pneumonia and wheezing in the first year: An international perspective       1 Dec 2015 In : Pediatric Pulmonology. 50, 12, p. 1277-1285

•             Mallol, J., Aguirre, V., Córdova, P., Cortez, E., Gallardo, A. & Riquelme, C.              Fraction of exhaled nitric oxide in healthy Chilean schoolchildren aged 8-15 years           1 Nov 2015 In : Allergologia et Immunopathologia. 43, 6, p. 528-532 5 p.

•             Solé, D., Filho, N. A. R., Sarinho, E. S., Camelo-Nunes, I. C., Barreto, B. A. P., Medeiros, M. L., Franco, J. M., Camargos, P. A., Mallol, J., Gurgel, R., De Andrade, D. M., Furlan, F. P., Silva, A. R., Cardozo, C. & Andrade, C.                Prevalence of asthma and allergic diseases in adolescents: Nine-year follow-up study (2003-2012). 1 Jan 2015 In : Jornal de Pediatria. 91, 1, p. 30-35 6 p.

•             Strachan, D. P., Aït-Khaled, N., Foliaki, S., Mallol, J., Odhiambo, J., Pearce, N. & Williams, H. C.    Siblings, asthma, rhinoconjunctivitis and eczema: A worldwide perspective from the International Study of Asthma and Allergies in Childhood    1 Jan 2015 In : Clinical and Experimental Allergy. 45, 1, p. 126-136 11 p.

•             Mascayano, C., Espinosa, V., Sepúlveda-Boza, S., Hoobler, E. K., Perry, S., Diaz, G. & Holman, T. R. Enzymatic studies of isoflavonoids as selective and potent inhibitors of human leukocyte 5-lipo-oxygenase              1 Jul 2015 In : Chemical Biology and Drug Design. 86, 1, p. 894-901 8 p.

•             Sáez-Briones, P., Soto-Moyano, R., Burgos, H., Castillo, A., Valladares, L., Morgan, C., Pérez, H., Barra, R., Constandil, L., Laurido, C. & Hernández, A.          β2-Adrenoceptor stimulation restores frontal cortex plasticity and improves visuospatial performance in hidden-prenatally-malnourished young-adult rats. 1 Mar 2015 In : Neurobiology of Learning and Memory. 119, p. 1-9 9 p.

•             Pereda, J., Sulz, L. & Monge, J. I. The role of the gastrointestinal epithelium as a possible pathway for the transfer of nutrients to the embryo's circulation               1 Jun 2015 In : Microscopy Research and Technique. 78, 6, p. 500-507 8 p.

•             Aranda, C. S., Wandalsen, G. F., Mallol, J., Solé, D., Prestes, E., Neto, H. C., Filho, N. R., Bianca, A. C. D., Medeiros, D., Sarinho, E., Moraes, L. S., Fernandes-Pontes, M. J. & Camargos, P. Wheezing and low birthweight 1 Feb 2015 In : Pediatric Allergy and Immunology. 26, 1, p. 82-85 4 p.

•             Morales-Camilo, N., Salas, C. O., Sanhueza, C., Espinosa-Bustos, C., Sepúlveda-Boza, S., Reyes-Parada, M., Gonzalez-Nilo, F., Caroli-Rezende, M. & Fierro, A.            Synthesis, biological evaluation, and molecular simulation of chalcones and aurones as selective MAO-B inhibitors     1 Jun 2015 In : Chemical Biology and Drug Design. 85, 6, p. 685-695 11 p.

•             Möller-Acuña, P., Contreras-Riquelme, J. S., Rojas-Fuentes, C., Nuñez-Vivanco, G., Alzate-Morales, J., Iturriaga-Vásquez, P., Arias, H. R. & Reyes-Parada, M.        Similarities between the binding sites of SB-206553 at serotonin type 2 and alpha7 acetylcholine nicotinic receptors: Rationale for its polypharmacological profile       5 Aug 2015 In : PLoS One. 10, 8, e0134444

•             Iturriaga-Vásquez, P., Alzate-Morales, J., Bermudez, I., Varas, R. & Reyes-Parada, M. .    Multiple binding sites in the nicotinic acetylcholine receptors: An opportunity for polypharmacolgy     3 Aug 2015 In : Pharmacological Research. 101, p. 9-17 9 p

•             Solé, D., Rosário Filho, N., Sarinho, E. C., Silva, A. R., Britto, M., Riedi, C., Cardozo, C., Camelo-Nunes, I. C., De Andrade, D. & Mallol, J.                  Prevalence of asthma and related symptoms in adolescents: Findings from 3 surveys                2015 In : Journal of Investigational Allergology and Clinical Immunology. 25, 1, p. 73-74 2 p.

•             Mallol J, Aguirre V, Gallardo A, Cortez E, Sánchez C, Riquelme C, Córdova P, Martínez M, Galindo A.        Effect of once-daily generic ciclesonide on exhaled nitric oxide in atopic children with persistent asthma.         Allergol Immunopathol (Madr). 2016 Mar-Apr;44(2):106-12. doi: 10.1016/j.aller.2015.01.011. Epub 2015 May 20.

•             Ramirez BU.       Correlation of self-assessment with attendance in an evidence-based medicine course. Adv Physiol Educ. 2015 Dec;39(4):378-82. doi: 10.1152/advan.00072.2015.

•             Aránguiz R, Chana-Cuevas P, Alburquerque D, Curinao X.              Focal dystonia in musicians: Phenomenology and musical triggering factors    Neurologia. 2015 Jun;30(5):270-5. doi: 10.1016/j.nrl.2013.12.024. Epub 2014 Aug 4.

•             Braithwaite I, Stewart AW, Hancox RJ, Beasley R, Murphy R, Mitchell EA               ISAAC Phase Three Study Group. Maternal post-natal tobacco use and current parental tobacco use is associated with higher body mass index in children and adolescents: an international cross-sectional study.             BMC Pediatr. 2015 Dec 24;15:220

•             Gonzalez MI, Grabenstatter HL, Cea-Del Rio CA, Cruz del Angel Y, Carlsen J, Laoprasert R; White AM; Huntsman MM, Brooks-Kayal A       Seizure-Related Regulation of GABAA Receptors in Spontaneously Epileptic Rats                Neurobiology of Disease.  Mar 11;77:246-256.  https://doi.org/10.1016/j.nbd.2015.03.001

•             Galaz P, Barra R, Figueroa H, Mariqueo T.             Advances in the pharmacology of lGICs auxiliary subunits.                 Pharmacol Res. 2015 Nov; 101:65-73. doi:10.1016/j.phrs.2015.07.026. Epub 2015 Aug 7. Review. PubMed PMID: 26255765

•             Bustos G, Renard GM, Noriega V, Sotomayor-Zárate R   HOW AND WHEN CHILEAN PHARMACOLOGY STARTED TO BE EXPERIMENTAL AND BECAME A SCIENCE Pharmacol Res. Nov;101:2-8.

•             Sotomayor-Zárate R, Abarca J, Araya KA, Renard GM, Andrés ME, Gysling K         EXPOSURE TO REPEATED IMMOBILIZATION STRESS INHIBITS COCAINE-INDUCED INCREASE IN DOPAMINE EXTRACELLULAR LEVELS IN THE RAT VENTRAL TEGMENTAL AREA       Pharmacol Res. Nov;101:116-23

•             Elena Alvareda, Pablo Miranda, Victoria Espinosa, Helena Pardo, Sara Aguilera & Margot Paulino Zunin 196 Antiinflamatory activity of phenolic compounds extracted from Uruguayan propolis and grape  J Biomol Struct Dyn. 2015;33 Suppl 1:129, DOI: 10.1080/07391102.2015.1032833

•             Jiménez Paneque, R., & Bachelet, V. C.  Clinical trials and study reporting - CONSORT guidelines at the forefront            Medwave, 15(8), e6273–e6273. https://doi.org/10.5867/medwave.2015.08.6273

•             Bachelet, V. C    A puppy and case reports in Medwave Medwave, 15(6), e6197–e6197. https://doi.org/10.5867/medwave.2015.06.6197

•             Bachelet, V. C    Impact and relevance of the journal: Publishing in English and large number of unique visits                Medwave, 15(10), e6301–e6301. https://doi.org/10.5867/medwave.2015.10.6301

•             Bachelet, V. C    Evidence and the Latin American region – dialogue or diatribe? Medwave, 15(3), e6127–e6127. https://doi.org/10.5867/medwave.2015.03.6127

•             Bachelet, V. C., & Baeza, B           Calling for qualitative health studies       Medwave, 15(5), e6167–e6167. https://doi.org/10.5867/medwave.2015.05.6167

•             Rada, G., & Bachelet, V. C            Living FRISBEE on Medwave: friendly and reliable evidence that is here to stay                Medwave, 15(7), e6232–e6232. https://doi.org/10.5867/medwave.2015.6232

•             Roldan, R (Roldan T, Rosa)[ 1,2 ] ; Torres, ME (Torres P, Maria Elena)[ 1 ] ; Gallardo, D (Gallardo M, Daniel)[ 1 ] ; Arias, M (Arias C, Marisol)[ 1 ] ; Saldias, F             Respiratory day hospital care for immunocompetent adult patients with community-acquired pneumonia  REVISTA MEDICA DE CHILE 143(4):467-474 DOI: 10.4067/S0034-98872015000400008

•             Neto, HJC (Chong Neto, H. J.); Wandalsen, GF (Wandalsen, G. F.); Dela Bianca, AC (Dela Bianca, A. C.); Aranda, C (Aranda, C.); Rosario, NA (Rosario, N. A.); Sole, D (Sole, D.); Mallol, J (Mallol, J.); Garcia-Marcos, L (Garcia-Marcos, L.)                Trends in prevalence and severity of recurrent wheezing in infants from Latin America  ALLERGY   Abstract de reunión: 1005  (70): 421-422  Suplemento: 101  Fecha de publicación: SEP 2015 

•             Aranda, C (Aranda, Carolina); Wandalsen, G (Wandalsen, Gustavo); Fonzar, L (Fonzar, Ligia); Dela Bianca, ACC (Dela Bianca, Ana Caroline C.); Mallol, J (Mallol, Javier); Sole, D (Sole, Dirceu) Risk Factors for Recurrent Wheezing - International Study of Wheezing in Infants (EISL) Phase 3             JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY  Abstract de reunión: 796. 135 ( 2): AB246-AB246  DOI: 10.1016/j.jaci.2014.12.1740  Suplemento: S   FEB 2015